Adult: Titrate dose for patients individually so as to achieve and maintain the lowest haemoglobin level sufficient to avoid … No trial has identified a hemoglobin target level, dose of this drug, or dosing strategy that does not increase these risks. Last updated on Nov 23, 2020. All chemotherapy patients: If the Hgb is more than 12 g/dL, withhold epoetin and once Hgb is less than 11 g/dL, resume at a dose 25% below the previous dose. -Initiate treatment if hemoglobin is less than 10 g/dL and a minimum of 2 additional months of chemotherapy is planned. Discontinue following the completion of a chemotherapy course. This drug is available at a higher level co-pay. To decrease these risks, as well as the risk of serious cardiovascular and thromboembolic reactions, use the lowest dose needed to avoid RBC transfusions. Return to Previous Page. ferrous sulfate, pyridoxine, Revlimid, Aranesp, Procrit, Vitamin B6, lenalidomide, epoetin alfa, Retacrit, Epogen. Most patients (82%) receiving an extended epoetin alfa regimen maintained Hb > or =11.0 g/dl. Adults—Dose is based on body weight and must be determined by your doctor. -Use the lowest dose necessary to avoid RBC transfusions. Initial dose: 50 to 100 units/kg IV or subcutaneously 3 times a week Do not use this drug if it has been shaken or frozen. Administration advice: How many biosimilars have been approved in the United States? Initial dose: 50 units/kg IV or subcutaneously 3 times a week Initial dose: 50 to 100 units/kg IV or subcutaneously 3 times a week 2005;64(2):113-123. 7. Patient advice: Drugs, 2003 Use ESAs only for anemia from myelosuppressive chemotherapy. -Contact Amgen (1-800-AMGEN) OR Janssen (1-800-JANSSEN) to perform assays for binding and neutralizing antibodies. By clicking send, you acknowledge that you have permission to email the recipient with this information. The recipient will receive more details and instructions to access this offer. -Pure red cell aplasia (PRCA) that begins after treatment with this or other erythropoietin protein drugs Restricted Access – Do not disseminate or copy without approval. Referenzen : Fachinformation Erypo®, Stand … Anämie infolge einer Chemotherapie 2. induzierter Anämie bei Krebspatienten 3. entzündlichen Darmerkrankung (Morbus Crohn und Colitis ulcerosa) 4. Data on file. Duration of therapy: Until completion of chemotherapy course All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. -Advise patients to seek medical attention for new/different neurologic symptoms. Epoetin Alfa is a synthetic form of a protein that regulates the formation of red blood cells in the body. Authorised by the European Medicines Agency on 28 August 2007, it stimulates erythropoiesis (increasing red blood cell levels) and is used to treat anemia, commonly associated with chronic kidney failure and cancer chemotherapy.. Epoetin is manufactured and marketed by Amgen under the trade … Using standardized doses helps eliminate errors … -Uncontrolled hypertension -Inform cancer patients that they must sign the patient-healthcare provider acknowledgment form before the start of each treatment course with this drug. It is also used during certain surgeries to decrease the need for blood transfusion. -If hemoglobin does not increase in 8 weeks, increase dose by 50 to 100 units/kg at 4 to 8 week intervals until hemoglobin reaches a level needed to avoid RBC transfusions or 300 units/kg. US BOXED WARNINGS: Do not re-enter preservative-free vials. Share cases and questions with Physicians on Medscape consult. -Monitor patients closely for premonitory neurologic symptoms during the first several months following initiation of this drug. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. -Benzyl alcohol-containing preparations of this drug are contraindicated in neonates and infants. -IV route is recommended for patients on hemodialysis. View the formulary and any restrictions for each plan. Background and objectives: The mortality risk associated with attempting to raise hemoglobin (Hb) levels by increasing Epoetin alfa (EPO) doses in hemodialysis patients with persistently low Hb remains poorly understood. Amgen; [Medicare patient exposure analysis; May 2014]. informational and educational purposes only. Use: Treatment of anemia due to zidovudine administered at 4200 mg/week or less in HIV-infected patients with endogenous serum erythropoietin levels of 500 milliunits/mL or less. Zidovudine treated patients: EPOGEN ® (epoetin alfa) prescribing information, Amgen. Postmarketing reports do not indicate a difference in safety profiles of pediatric patients with CKD requiring dialysis and not requiring dialysis. The dose of this medicine will be different for different patients. Discontinue if responsiveness does not improve. -Protect from light. -Inform patients of the need to have regular laboratory tests for hemoglobin. Evaluate other causes of anemia. Adult: 600 units/kg 2 times a wk starting 3 wk before surgery. -If hemoglobin increases by less than 1 g/dL and remains below 10 g/dL after 4 weeks of therapy, increase dose to 300 units/kg 3 times a week or 60,000 units once a week in adults or 900 units/kg (60,000 units maximum) once a week in children. Adult: 2004;61(6):392-405. -Use of multiple-dose/benzoyl alcohol-containing products in neonates, infants, pregnancy, or lactation Initial dose: 50 to 100 units/kg IV or subcutaneously 3 times a week To enroll in the ESA APPRISE Oncology Program, visit www.esa-apprise.com or call 1-866-284-8089 for further assistance. Comments: ... Single-dose, Preservative-free Vial (in phosphate-buffered formulation): Each 1 mL of solution contains 40,000 Units (NDC 59676-340-01) of epoetin alfa and is supplied in dispensing packs containing 4 single-dose vials. This protein may be reduced when you have kidney failure or use certain medications. Manage and view all your plans together – even plans in different states. Did the Wise Men Notice the Babinski Sign in the Christ Child? commonly, these are "non-preferred" brand drugs. The following information includes only the average doses of this medicine. -Initiate treatment only when hemoglobin is less than 10 g/dL, rate of hemoglobin decline indicates likelihood of requiring RBC transfusion, and reducing risk of alloimmunization and/or other RBC transfusion-related risks is a goal. DESCRIPTION. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvZXBvZ2VuLXByb2NyaXQtZXBvZXRpbi1hbGZhLTM0MjE1MQ==, View explanations for tiers and If you log out, you will be required to enter your username and password the next time you visit.